Research on Ultrasound Diagnostic Criteria for Intracranial and Extracranial Arterial Serial Sten… (NCT06947720) | Clinical Trial Compass
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Research on Ultrasound Diagnostic Criteria for Intracranial and Extracranial Arterial Serial Stenosis
China700 participantsStarted 2025-09-01
Plain-language summary
This study utilized different hemodynamic parameters of transcranial color-coded Doppler (TCCD) and transcranial Doppler (TCD) to conduct ultrasonic grading evaluation on middle cerebral artery (MCA) stenosis severity in patients with severe extracranial internal carotid artery stenosis, as well as intracranial V4 segment stenosis severity in patients with severe vertebral artery (VA) origin stenosis. The aim was to establish ultrasonic diagnostic criteria and provide reference basis for clinical treatment decision-making. Clarify the distribution of stroke risk factors, establish and evaluate stroke risk identification and prediction models. Patient cohort: Individuals undergoing carotid artery stenting or vertebral artery stenting, including those with either 1) severe extracranial internal carotid artery stenosis combined with ipsilateral MCA tandem stenosis, or 2) unilateral severe vertebral artery origin stenosis combined with intracranial V4 segment tandem stenosis. Collected data included demographic information, vascular ultrasound findings, and imaging examination results. All patients underwent a 1-year follow-up investigation documenting follow-up vascular ultrasound results, laboratory test results, imaging findings, clinical symptoms (ischemic stroke, transient ischemic attack, hemorrhagic stroke), and occurrence of endpoint events.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Patients diagnosed by carotid ultrasound with severe stenosis of the extracranial segment of the internal carotid artery or severe stenosis of the initial segment of the unilateral vertebral artery;
✓. Perform stent placement surgery within 2 weeks of ultrasound examination, and perform DSA and CTA examinations;
✓. Age ≥ 18 years old;
✓. Clinical data is complete.
Exclusion criteria
✕. Bilateral temporal windows are not transparent to sound;
✕. Patients with severe stenosis of the extracranial segment of the internal carotid artery have ipsilateral MCA occlusion/ipsilateral common carotid artery severe stenosis or occlusion;
✕. Patients with severe stenosis of the extracranial segment of the internal carotid artery have severe stenosis of the contralateral carotid artery;
✕. Patients with severe stenosis or occlusion of the anterior circulation in the initial segment of unilateral vertebral artery;
What they're measuring
1
Ultrasound diagnostic criteria for serial stenosis
Timeframe: From preoperative TCCD assessment to surgical completion