Not Yet RecruitingNot Applicable

Immunity With Acute Hepatits A

50 participantsStarted 2025-10-01

Plain-language summary

Hepatitis A Virus (HAV) is a public health concern in Egypt, especially among children. Historically highly endemic, recent studies suggest a changing epidemiology. While improved socioeconomic conditions have reduced its spread, HAV remains prevalent, with over 50% of Egyptians exposed by age 15. Infection is often asymptomatic or mild in children but can be more severe with age. Prevention relies on improved sanitation and hygiene, with vaccin and recov

Who can participate

Age range1 Year – 15 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Children aged 1-15 years * Confirmed diagnosis of acute hepatitis A infection (positive anti-HAV IgM) * Admitted to the hospital for management of acute hepatitis A * Parental/guardian consent and child assent (where appropriate) obtained Exclusion Criteria: * Known pre-existing liver disease or chronic hepatitis * Immunodeficiency disorders or current immunosuppressive therapy * Coinfection with other hepatotropic viruses (HBV, HCV, HEV) * Severe malnutrition * Recent blood transfusion (within 3 months)

What they're measuring

Correlation between lymphocyte subset levels and development of hepatic encephalopathy or fulminant hepatic failure

Timeframe: One year

Trial details

NCT IDNCT06942962

SponsorAssiut University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-10-01

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