Perioperative Colchicine for TKA

Inclusion Criteria: * Patients 18 years or older undergoing elective total knee arthroplasty for osteoarthritis. Exclusion Criteria: * Subject has impaired hepatic function (Child-Pugh Class \>B) * Subject has impaired renal function (GFR \< 60 ml/min/1.73 m2) * Subject has known adverse reaction to colchicine * Subject has chronic opioid use (Filled opioid medication twice within 6 months of surgical date) * Subject is pregnant or expecting to become pregnant during the time of the study associated with colchicine exposure (postoperative days 0-3) * Subject is unable to provide informed consent * Subject is actively prescribed medication that interact with colchicine in a manner that would increase the risk of colchicine toxicity, i.e.: * Antifungals: Ketoconazole, itraconazole, fluconazole, etc… * Macrolides : Clarithromycin, erythromycin * HIV protease : Ritonavir, Atazanavir, saquinavir, etc... * Ca2+: Verapamil and Diltiazem * Cyclosporine * Danazol * Amiodorone * Quinidine * Anti-hepaciviral combinations * Grapefruit juice * Statins: atorvastatin, lovastatin, simvastatin, etc… * Gemfibrozil and other fibrates * Digoxin