Comparison of IL-8, FGF-1 and VEGF Levels in Pulpal Tissue, GCF and Dentinal Fluid Samples of Healthy, Reversible and Irreversible Pulpitis Diagnosed Teeth

Inclusion Criteria: Control group: * Unrestored, caries-free vital teeth with healthy pulp * Orthodontically indicated teeth for extraction * wisdom teeth indicated for extraction in terms of oral hygiene * teeth that require root canal treatment for prosthetic purposes Reversible pulpitis group: * Teeth that react mildly to cold, hot, sour or sweet stimuli * Teeth with no history of spontaneous pain * Teeth that respond to cold test and electric pulp test within normal limits * Teeth that are not sensitive to chewing or percussion Irreversible pulpitis group: * Teeth with a history of continuous moderate or severe spontaneous pain * Teeth sensitive to percussion * Teeth without periapical pathology Exclusion Criteria: * Patients requiring antibiotic prophylaxis. * Patients with diabetes or haematological diseases. * Patients who have used antibiotics or anti-inflammatory drugs in the last three weeks. * Patients who are pregnant during treatment. * Patients with intense plaque and tartar on their teeth, redness and bleeding in the gums. * Patients with severe gingivitis, generalised periodontitis or periodontal pocket depth of more than 3 mm. * Patients with no response to pulp sensitivity tests, presence of sinus tract, presence of periapical pathology on radiography. * Teeth without pulp exposure after caries removal