RecruitingNot Applicable

Feasibility of Tracheobronchial Defect Reconstruction Using Allogenic Aortic Patch

Taiwan10 participantsStarted 2025-09-15

Plain-language summary

The investigators investigate the feasibility and safety of using cryopreserved aortic patches for tracheal or bronchial defect repair.

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Congenital tracheal deformities: Includes congenital tracheomalacia, congenital tracheobronchial malformations, complete tracheal rings, etc., with severe clinical symptoms and cases where treatment is recommended after evaluation.
✓. Acquired tracheal stenosis: Includes tracheal narrowing caused by diseases, endotracheal intubation, or postoperative scar tissue, with severe clinical symptoms and cases where treatment is recommended after evaluation.
✓. Tracheal injury or tissue defect caused by trauma or burns: Cases requiring surgical repair.
✓. Tracheal tumors: Reconstruction of tracheal tissue following the removal of benign or malignant tumors.

✕. Patients who are unable to provide informed consent.
✕. Pulmonary tumors that can be treated with standard lobectomy.
✕. Locally invasive tumors that are unresectable.
✕. Presence of contralateral lymph node metastasis.
✕. Presence of distant metastasis, except for solitary, resectable brain metastasis.
✕. Tracheal lesions amenable to standard resection with direct anastomosis.
✕. Preoperative evaluation indicates inability to undergo standard lobectomy.
✕. Patients infected with human immunodeficiency virus (HIV) or with other immunodeficiency disorders.

90-day mortality

Timeframe: 90 days

NCT IDNCT06935110

SponsorNational Taiwan University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-07-31

Chao-Wen Lu, MD

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Congenital tracheal deformities: Includes congenital tracheomalacia, congenital tracheobronchial malformations, complete tracheal rings, etc., with severe clinical symptoms and cases where treatment is recommended after evaluation.
✓. Acquired tracheal stenosis: Includes tracheal narrowing caused by diseases, endotracheal intubation, or postoperative scar tissue, with severe clinical symptoms and cases where treatment is recommended after evaluation.
✓. Tracheal injury or tissue defect caused by trauma or burns: Cases requiring surgical repair.
✓. Tracheal tumors: Reconstruction of tracheal tissue following the removal of benign or malignant tumors.

✕. Patients who are unable to provide informed consent.
✕. Pulmonary tumors that can be treated with standard lobectomy.
✕. Locally invasive tumors that are unresectable.
✕. Presence of contralateral lymph node metastasis.
✕. Presence of distant metastasis, except for solitary, resectable brain metastasis.
✕. Tracheal lesions amenable to standard resection with direct anastomosis.
✕. Preoperative evaluation indicates inability to undergo standard lobectomy.
✕. Patients infected with human immunodeficiency virus (HIV) or with other immunodeficiency disorders.