Evaluation of the Potential Effects of LRP5 and Tph1 in the Pathogenesis of Periodontal Disease Individuals With Stage III Grade B Periodontitis

Inclusion Criteria: * \>18 years old, * At least 16 permanent teeth except 3rd molars, * Individuals who do not use orthodontic appliances, * Individuals who are not pregnant or lactating, * Individuals without any systemic disease that may affect periodontal health, * Systemically healthy individuals, * Individuals who have not used anti-inflammatory and/or anti-microbial drugs in the last 6 months, * Individuals who have not received periodontal treatment in the last 1 year Exclusion Criteria: * Pregnant/lactating individuals, * Individuals who have used anti-inflammatory and/or anti-microbial drugs in the last 6 months, * Individuals who have undergone periodontal treatment in the last 1 year, * Individuals with psychiatric illness, * Individuals with any oral infection, * Individuals with \<16 teeth, excluding molars, * Individuals with alcohol dependence, * Individuals with active infectious disease (acute hepatitis, AIDS, tuberculosis), cancer or any systemic condition that may affect periodontal tissues, * Individuals receiving treatment with drugs known to affect periodontal tissues (phenytoin, cyclosporine A, calcium channel blockers)