The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lic… (NCT06932848) | Clinical Trial Compass
RecruitingNot Applicable
The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lichen Planus
Thailand30 participantsStarted 2025-06-01
Plain-language summary
This randomized, double-blind clinical trial evaluates the therapeutic effects of curcumin in nanogels compared to 0.1% fluocinolone acetonide oral paste in the management of atrophic-erosive oral lichen planus (OLP). The study aims to determine whether curcumin nanogels, a natural treatment with enhanced bioavailability, are as effective and better tolerated than standard corticosteroid therapy.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 years or older
* Ability to provide written informed consent
* Clinically and histopathologically confirmed diagnosis of erosive or atrophic oral lichen planus (OLP)
* Presence of symptoms (NRS pain score \> 0 at baseline)
* Ability to communicate and follow instructions
* Willingness to apply oral paste treatment and comply with study protocol
Exclusion Criteria:
* Pregnancy or lactation
* Current orthodontic treatment
* Uncontrolled diabetes mellitus (HbA1c \> 7% or FPG \> 130 mg/dL)
* Use of anticoagulants or antiplatelet agents
* Severe dry mouth (Challacombe score \> 7)
* History of gastric ulcers, duodenal ulcers, or gallstones
* Presence of any active malignancy or infection
* Use of topical/systemic treatment for OLP in the past 2 weeks
* Current use of immunosuppressants
* Known allergy to corticosteroids or herbal agents such as turmeric
* Diagnosis of oral lichenoid contact lesion or graft-versus-host disease (GVHD)
* History of allogeneic bone marrow transplantation
* Current smokers
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.