PVI Alone vs PVI With Posterior Wall Isolation for Pulse-Field Ablation in Persistent AF (NCT06929897) | Clinical Trial Compass
By InvitationNot Applicable
PVI Alone vs PVI With Posterior Wall Isolation for Pulse-Field Ablation in Persistent AF
South Korea482 participantsStarted 2026-07-03
Plain-language summary
To date, no optimal treatment has been established to improve outcomes in patients with persistent atrial fibrillation. The safety and efficacy of pulsed-field ablation (PFA) have been demonstrated in several studies, and its clinical application is expanding.
\- In patients with persistent atrial fibrillation, can the addition of posterior wall isolation (PWI) following pulmonary vein isolation (PVI) using PFA reduce recurrence?
Participants will:
* Undergo either PVI alone or PVI with additional left atrial posterior wall isolation (PWI)
* Visit the clinic to assess for recurrence of atrial tachyarrhythmias
Who can participate
Age range
20 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged 20 to 80 years who are candidates for catheter ablation for persistent atrial fibrillation
* Patients eligible for catheter ablation according to existing clinical guidelines
* Those without clinically significant structural heart disease (e.g., severe mitral regurgitation)
* Those without contraindications to anticoagulation therapy
Exclusion Criteria:
* Atrial fibrillation associated with severe congenital heart disease or structural heart disease
* Patients with contraindications to general anesthesia or sedation for the procedure
* History of prior cardiac surgery (e.g., Maze procedure, coronary artery bypass grafting)
* History of atrial fibrillation catheter ablation within the past 12 months
* Patients with severe left ventricular dysfunction (left ventricular ejection fraction \<30%)
* Patients with active internal bleeding
* Patients with contraindications to anticoagulation therapy and antiarrhythmic drugs
* Valvular atrial fibrillation (e.g., mitral stenosis \> grade 2, mechanical valve, prior mitral valve repair)
* Patients with severe comorbid conditions
* Patients with an expected survival of less than one year
* Patients with drug or alcohol addiction
* Pregnant or breastfeeding women
* Any other conditions deemed by the investigator to make the patient unsuitable for study participation
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Recurrence of atrial tachyarrhythmia
Timeframe: Within 12 months after the procedure, excluding the first 4-week blanking period