Multiple micronutrients play an important role during pregnancy, since the decidualization and implantation phases. It has an impact on placentation and remodeling of blood vessels. The optimal early pregnancy conditions accompanied by great angiogenesis and vasculogenesis factors will influence fetal growth. This study aims to determine the effect of maternal multiple micronutrient supplementation on angiogenesis factors, vasculogenesis factors, and fetal biometry. It is a clustered randomized controlled trial that aims to determine the impact of maternal micronutrient supplementation on PlGF levels, sFlt-1/PlGF ratio, mean pulsatility index of uterine artery, and fetal biometry (head circumference, femur length, and estimated fetal weight percentile). The target population for the study was all pregnant women who underwent antenatal check-ups at community health centers in DKI Jakarta.
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PlGF levels
Timeframe: It was carried out at gestational age: 1. Trimester 1: 8-14 weeks. 2. Trimester 2: 20-26 weeks.
sFlt-1/PlGF ratio
Timeframe: 20-26 weeks of gestation
mean pulsatility index of uterine artery
Timeframe: 1. Trimester 1 : 8-14 weeks. 2. Trimester 2 : 20-26 weeks.
Head circumference
Timeframe: 20-26 weeks of gestation
Femur length
Timeframe: 20-26 weeks of gestation
Estimated fetal weight
Timeframe: 20-26 weeks of gestation