CompletedNot Applicable

Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction

United States30 participantsStarted 2025-05-30

Plain-language summary

The purpose of this study is to find out if additional images taken during a stress echocardiogram study and risk score calculation will help the doctor determine if shortness of breath or chest pain are caused by stiff heart (heart failure with preserved ejection fraction or HFpEF).

Who can participate

Age range

50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Clinically indicated exercise stress echo for the evaluation of exertional dyspnea or chest pain * Age ≥50 years Exclusion Criteria: * Known history of HFpEF * LVEF \<50% on baseline echo study * History of hypertrophic cardiomyopathy, amyloidosis, or pulmonary arterial hypertension, severe right ventricular dysfunction and severe valvular disease based on chart review or baseline echo study * History of organ transplant (heart, kidney, liver, lungs) * Severe pulmonary disease requiring ambulatory oxygen therapy * End-stage renal disease requiring long-term renal replacement therapy * Decompensated liver disease * Conditions that prevent accurate assessment of E/e' ratio (mitral prosthetic valve, severe mitral annular calcification) * Plan to use echo contrast agent during stress study (i.e. contrast agent needed for baseline study) * Patients from outside Duke health system with no plan for long-term care at Duke

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

HFpEF clinic visit at 1 month and 6 months

Timeframe: Within 6 months of participant enrollment

Confirmed HFpEF diagnosis at 1 month and 6 months

Timeframe: Within 6 months of participant enrollment

Estimate the prevalence of undiagnosed HFpEF in patients undergoing exercise stress echo using HFpEF probability score and exercise echo filling pressure assessment

Timeframe: Within 6 months of participant enrollment

Trial details

NCT IDNCT06927973

SponsorDuke University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-19

View on ClinicalTrials.gov More Chest Pain trials

Who can participate

Age range

50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

HFpEF clinic visit at 1 month and 6 months

Timeframe: Within 6 months of participant enrollment

Confirmed HFpEF diagnosis at 1 month and 6 months

Timeframe: Within 6 months of participant enrollment

Estimate the prevalence of undiagnosed HFpEF in patients undergoing exercise stress echo using HFpEF probability score and exercise echo filling pressure assessment

Timeframe: Within 6 months of participant enrollment