RecruitingNot Applicable

Antidepressant Response of DMT Masked With Propofol

Switzerland112 participantsStarted 2025-08-05

Plain-language summary

The aim of this study is to elucidate if the anti-depressive effect of N,N-dimethyltryptamine (DMT) is based on a biological mechanisms including neuroplasticity and anti-inflammatory effect or due to the subjective psychedelic experience.

Who can participate

Age range

21 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Participants must meet DSM-5 criteria for MDD of at least moderate severity (MADRS≥20).
. Participants either currently do not use antidepressants or are treated with a stable dose for at least 4 weeks prior to randomization.
. Age ≥ 21 years old.
. Sufficient understanding of the German language.
. Able to understand the study procedures and risks and willing to adhere to the protocol and sign the consent form.
. Willing not to drive or operate heavy machinery on the treatment day.
. Willing to refrain from more than 7 standard alcoholic drinks a week, more than 10 cigarettes a day, more than 2 cups of coffee a day, and any illicit substances during study participation.
. Willing to use effective contraceptive measures throughout study participation.

Exclusion criteria

. Past or present bipolar or psychotic disorder, including depressive disorder with psychotic features.
. First-degree relative with a psychotic or bipolar disorder.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

long term changes in depressive symptoms (MADRS)

Timeframe: baseline (before intervention) and on day 14 post-intervention

Trial details

NCT IDNCT06927076

SponsorUniversity Hospital, Basel, Switzerland

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-03

Contact for this trial

Joyce Santos de Jesus

+41 61 556 65 02 DMT4D@usb.ch

View on ClinicalTrials.gov More Major Depressive Disorder trials