By InvitationNot Applicable

Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair

Egypt108 participantsStarted 2025-10

Plain-language summary

Management of non-vital primary molars is challenging due to the natural anatomy of primary teeth, patients' young age, and their behavior toward dental treatment. A simple and effective technique such as Lesion Sterilization and Tissue Repair offers a solution to cases with poor prognosis; however, the medicaments used in this technique have some limitations. This study will evaluate three different medicaments regarding the clinical success, radiographic success, and antibacterial activity.

Who can participate

Age range4 Years – 8 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy cooperative children of both sexes in the age range of 4-8 years old. * Children with consenting parents who accept to participate in the study and sign the consent forms. * Children with mandibular primary molars with clinical and radiographic signs of pulpal necrosis. Exclusion Criteria: * Children with hypersensitivity to any of the used medicaments. * Non-restorable teeth without sufficient coronal structure for placement of rubber dam isolation and restoration with stainless steel crowns * Non-restorable teeth with perforated pulpal floor

What they're measuring

Clinical success

Timeframe: 1,6, and 12 months follow up

Radiographic success

Timeframe: 6 and 12 months follow up

Trial details

NCT IDNCT06926322

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-08

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