Efficacy and Safety of Endovascular Thrombectomy in Acute Ischemic Stroke With Posterior Circulat… (NCT06924996) | Clinical Trial Compass
By InvitationNot Applicable
Efficacy and Safety of Endovascular Thrombectomy in Acute Ischemic Stroke With Posterior Circulation Large Infarct
China500 participantsStarted 2023-01-01
Plain-language summary
The purpose of this study is to evaluate whether endovascular thrombectomy (EVT) combined with best medical management (BMM) leads to better functional outcomes than BMM alone in patients with acute basilar artery occlusion with posterior circulation large infarct.
Who can participate
Age range18 Years – 80 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Age 18-80 years old;
✓. Acute ischemic stroke in the posterior circulation, the onset of stroke (or last well known) to the enrollment time within 24 hours;
✓. Posterior circulation large infarct: NCCT or DWI showed pc-ASPECTS ≤ 5 points, or pontine midbrain index (PMI) ≥ 3 points;
✓. NIHSS score ≥10 points after the onset of the stroke and before enrollment;
✓. Able to live independently before the onset of the disease (mRS score ≤2 points);
✓. The subject or legal representative is able to sign the informed consent form.
Exclusion criteria
✕. Intracranial hemorrhage (except microhemorrhage) on CT/MRI ;
✕. CT/MRI revealed large infarction in the cerebellar hemisphere, with significant mass effect causing compression of the fourth ventricle or brainstem;
✕. CT or MRI showed bilateral complete thalamic infarction;
✕. Occlusion of anterior and posterior circulation arteries confirmed by CTA/MRA/DSA;
✕. The presence of intracranial tumors (except for small meningiomas and cerebral aneurysms with a diameter of \<3mm);
What they're measuring
1
Rate of modified Rankin scale 0-3 at 90 (±14) days after enrollment
. Patients with known or highly suspected chronic basilar artery occlusion.;
✕. Known severe allergy to contrast agents (except for mild rash);
✕. Refractory hypertension (defined as systolic blood pressure \> 185 mmHg or diastolic blood pressure \>110 mmHg) that cannot be controlled by drug therapy;