CompletedNot Applicable

Medical and Surgical Treatment of MRONJ (Medication-related Osteonecrosis of the Jaw Bones)

Turkey (Türkiye)102 participantsStarted 2018-01-01

Plain-language summary

MRONJ is an acronym used to describe medication-related osteonecrosis of the jaw bones. It has been reported by the AAOMS that bisphosphonates or denosumab can cause this condition. The management of medication-related osteonecrosis of the jaw (MRONJ) is challenging, and there is ongoing debate over whether medical or surgical treatment is the gold standard. The aim of this retrospective study is to investigate the efficacies of medical and surgical treatments of MRONJ and comparatively evaluate their outcomes.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Use of antiresorptive and/or antiangiogenic drugs and consequent development of MRONJ. * Absence of head and neck radiotherapy. * Presence of necrotic bone in the maxillofacial region for at least 8 weeks. Exclusion Criteria: * Having undergone head and neck radiotherapy. * Presence of active radiotherapy and/or chemotherapy. * Missing information in treatment and follow-up records

What they're measuring

Healing status of MRONJ lesions after medical vs surgical treatment

Timeframe: Treatment outcomes were assessed after 12 months.

Trial details

NCT IDNCT06917846

SponsorAkdeniz University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-01-01

View on ClinicalTrials.gov More Osteonecrosis Due to Drugs, Jaw trials