RecruitingNot Applicable

Renal Perfusion and the Development of AKI Following Traumatic Injury

United Kingdom20 participantsStarted 2024-04-13

Plain-language summary

Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk. Although septic shock patients who develop severe AKI are known to develop hypoperfusion of the renal cortex, little is known regarding intra-renal perfusion changes in THS. The aim of the current study is to investigate the effects of THS on renal microcirculatory perfusion.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age \> 18 years * Within 24 hours of ICU admission following traumatic injury * Received any blood products during initial resuscitation * Lactate \> 2 mmol/l at any stage prior to study enrolment Exclusion Criteria: * Known intolerance to Sonovue or any other ultrasound contrast agent * Patients with un-survivable injuries / not expected to survive 24 hours in whom the intent of treatment is palliative * Known CKD 4 or end stage renal failure * Pregnancy

What they're measuring

Cortical mean transit time (mTT) measured in seconds

Timeframe: Measured at enrollment, +24 hours and + 48 hours

Trial details

NCT IDNCT06917053

SponsorKing's College Hospital NHS Trust

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-01

Contact for this trial

Sam Hutchings

+442032994957 sam.hutchings@nhs.net

View on ClinicalTrials.gov More Traumatic Haemorrhagic Shock trials