This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with opioids, or inhalational anesthesia with opioids. The study will measure blood levels of inflammation-related substances (such as IL-6, CRP, cortisol, ESR , WBC and lactate) at several time points before and after surgery. Heart rate variability will also be monitored as an indicator of the body's stress response. The results may help identify anesthesia strategies that reduce inflammation and improve recovery in patients undergoing bariatric surgery.
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Serum IL-6 Level
Timeframe: Preoperative (baseline), immediately after surgery, and 24 hours post-surgery.
C-reactive Protein (CRP) Level
Timeframe: Preoperative (baseline), immediately after surgery, and 24 hours post-surgery.
Serum Cortisol Level
Timeframe: Preoperative (baseline), immediately after surgery, and 24 hours post-surgery.
Heart Rate Variability (HRV) as an Inflammatory Marker
Timeframe: Collected continuosly from the induction of the anesthesia until the end of surgery
Serum Lactate Level
Timeframe: Preoperative (baseline), immediately after surgery, and 24 hours post-surgery.
Erythrocyte Sedimentation Rate (ESR)
Timeframe: Preoperative (baseline), immediately after surgery, and 24 hours post-surgery.
Differential White blood Cell count (WBC).
Timeframe: Preoperative (baseline), immediately after surgery, and 24 hours post-surgery.
Hipolito Labandeyra Gonzalez, Anesthesiologist