Not Yet RecruitingNot Applicable

Esketamine Combined With PRF of DRG for Acute/Subacute Zoster-associated Pain

China184 participantsStarted 2025-04-01

Plain-language summary

To assess the 1-month effects and safety of esketamine - PRF -standardized drug treatment against PRF -standardized drug treatment acute/subacute zoster-associated pain (ZAP) patients.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Ages more than 18 years;
. Patients with onset of herpes zoster (HZ) rash less than 90 days;
. HZ affected the spinal nerves (cervical/thoracic/lumbar nerve);
. Having an average pain score of at least 4 on a Numeric Rating Scale (NRS, 0 = no pain, 10= worst possible pain)；
. Planned to perform CT-guided PRF treatment of the dorsal root ganglion(DRG).

Exclusion criteria

. Obstructive sleep apnoea syndrome;
. Those who receive other more invasive treatments, such as radiofrequency thermocoagulation (RFT) of DRG.
. A history of systemic immune diseases, organ transplantation, or cancers;
. A history of severe cardiopulmonary, hepatic, renal dysfunction or coagulation function disorder;
. A history of schizophrenia, epilepsy, or myasthenia gravis, delirium;
. Comorbid hyperthyroidism or phaeochromocytoma;

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

the NRS score at 1 month after treatment.

Timeframe: 1-month period

Trial details

NCT IDNCT06914206

SponsorBeijing Tiantan Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-04-01

Contact for this trial

Fang Luo

+86 13611326978 13611326978@163.com

View on ClinicalTrials.gov More Herpes Zoster trials