Esketamine Combined With PRF of DRG for Postherpetic Neuralgia (NCT06914193) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Esketamine Combined With PRF of DRG for Postherpetic Neuralgia
China186 participantsStarted 2025-04-01
Plain-language summary
This trial's primary objective is to compare the analgesic efficacy of esketamine in combination with pulsed radiofrequency (PRF) of dorsal root ganglion(DRG) against that of PRF monotherapy in patients with postherpetic neuralgia(PHN).
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Ages more than 18 years;
. Pain persisting for over three months following the onset of the herpes zoster skin rash;
. Lesions located in in the unilateral cervical, thoracic, and lumbosacral segments;
. Having an average pain score of at least 4 on a Numeric Rating Scale (NRS, 0 = no pain, 10= worst possible pain)； Planned to perform CT-guided PRF treatment of the Dorsal root ganglion（DRG）
Exclusion criteria
. Obstructive sleep apnoea syndrome;
. Those who receive other more invasive treatments, such as radiofrequency thermocoagulation (RFT) of DRG.
. A history of systemic immune diseases, organ transplantation, or cancers;
. A history of severe cardiopulmonary, hepatic, renal dysfunction or coagulation function disorder;
. A history of schizophrenia, epilepsy, or myasthenia gravis, delirium;
. Comorbid hyperthyroidism or phaeochromocytoma;
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
The primary comparison is the difference between the means of the daily mean pain scores over the first 7 days, measured on an 11-point NRS