Not Yet RecruitingPhase 2/3

Semaglutide for the Prevention Of Post-Transplant Diabetes Mellitus

Canada74 participantsStarted 2026-01-05

Plain-language summary

The study aims to determine the short-term efficacy, mechanisms and safety of 24 weeks of placebo and semaglutide therapy in 74 KTR at risk of post-transplant diabetes mellitus (PTDM).

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Signed and dated written informed consent.
. Adult (≥18 years) recipients of a living or deceased donor kidney transplant
. Between 4- and 12-weeks post kidney transplant
. Stable kidney function defined as an eGFR \> 30 ml/min/1.73m2 (CKD-EPI)
. At risk for PTDM at the time of transplant based on the following criteria:
. BMI ≥ 25 kg/m2, or
. Fasting plasma glucose 6.1-6.9 mmol/L (impaired fasting glucose), or
. 2hr OGTT plasma glucose 7.8-11.0 (impaired glucose tolerance), or

Exclusion criteria

. Established diagnosis of type 1 or type 2 DM as per Diabetes Canada (including the need for glucose-lowering therapy for hyperglycemia at the time of screening)
. Kidney-Pancreas transplant recipient
. Acute coronary syndrome, transient ischemic attack or stroke within 30 days prior to screening

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

2-hour OGTT

Timeframe: 24 weeks

Trial details

NCT IDNCT06913023

SponsorUniversity Health Network, Toronto

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-11-30

Contact for this trial

Vesta Lai

416-340-4800 vesta.lai@uhn.ca

View on ClinicalTrials.gov More Kidney Transplant Recipient trials