Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)

Exclusion criteria

• ✕. Active liver disease (Child-Pugh class B-C), cirrhosis, nor active alcoholism.
• ✕. History of myopathy/rhabdomyolysis.
• ✕. History of acute myocardial infarction or severe coronary disease.
• ✕. Pregnant/post-menopausal, or male.
• ✕. History of diabetes mellitus.
• ✕. Allergy/hypersensitivity to Hydroxymethylglutaryl-coenzyme A (HMG Co-A) reductase inhibitor and/or xanthine derivatives, e.g., caffeine, theophylline, theobromine.
• ✕. Contraindications for MRI Subject to the discretion of the treating physician and Principal Investigator (PI), as the MRI may be optional
• ✕. Participants who are receiving any other investigational agents.