RecruitingNot Applicable

Bilateral Single-Electrode VO Combined With STN-DBS for Treating Meige Syndrome

China20 participantsStarted 2025-03-06

Plain-language summary

Meige syndrome is a rare and debilitating movement disorder characterized by blepharospasm, oromandibular dystonia, and cervical muscle contractions, often refractory to pharmacological therapies. Deep brain stimulation (DBS), initially developed to treat essential tremor and Parkinson's disease, has been explored in recent years as a potential treatment for various dystonias, including Meige's syndrome. This clinical study aims to evaluate the safety and efficacy of bilateral single-electrode ventralis oralis (VO) nucleus stimulation combined with subthalamic nucleus deep brain stimulation (STN-DBS) in patients with Meige syndrome.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Must meet the clinical diagnostic criteria for Meige syndrome * Only includes patients with: Blepharospasm-type Meige syndrome and Blepharospasm with lower jaw muscle dystonia-type * All patients must have undergone at least one year of systematic and standard treatment prior to surgery Exclusion Criteria: * History of neurological diseases other than Meige syndrome * Severe cognitive impairment * Severe psychiatric disorders

What they're measuring

Improvement of primary symptoms

Timeframe: 1 year after stimulation

Trial details

NCT IDNCT06912282

SponsorHuashan Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-30

View on ClinicalTrials.gov More Meige Syndrome trials