Understanding Individual Variability in Neuronal Signal Transmission to Target Organs in Health a… (NCT06912048) | Clinical Trial Compass
RecruitingNot Applicable
Understanding Individual Variability in Neuronal Signal Transmission to Target Organs in Health and Disease
Germany52 participantsStarted 2025-05-14
Plain-language summary
The goal of this clinical trial is to evaluate the influence of parasympathetic transmission from the brain to different metabolic organs. This transmission can be blocked with the muscarinic antagonist atropine.
Participants will undergo an oral glucose tolerance test combined with a double tracer dilution technique either with atropine infusion or placebo.
Healthy individuals and high-risk individuals will be compared to identify possible changes in signaling in high-risk groups. In addition, men and women will be included to take into account possible sex differences.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age: at least 18
* BMI: 20 - 24.9 kg/m2 (for the healthy groups) or more than 28 kg/m2 (for the overweight groups)
* For women: Hormonal contraception with a single-phase preparation (e.g. Nuvaring)
* Understanding and voluntarily signing an informed consent form prior to study-related examinations
Exclusion Criteria:
* Drug and/or alcohol abuse
* smoking
* Taking medication that affects blood sugar or addresses the central and/or autonomic nervous system (e.g. anti-epileptic drugs, beta blockers, dopamine agonists, antidepressants). Taking antihistamines.
* Pre-existing cardiac conditions
* Neurological pre-existing conditions
* Known cardiac arrhythmia
* Known allergies to ingredients, e.g. paracetamol and atropine
* Known narrow-angle glaucoma
* Known hyperthyroidism
* Known diseases of the urinary tract or prostate
* Pregnancy or breastfeeding
* At screening: Hb \< 12 g/dl for women and Hb \< 14 g/dl for men
* No consent to be informed about incidentally discovered pathological findings
* Any (clinical) condition which, in the opinion of the physician, could jeopardize the safety of the
* or would jeopardize the scientific success.
* Liver dysfunction
* Renal insufficiency
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.