Impact of Perioperative Organ Resuscitation of Brain-dead Deceased Organ Donor on Kidney Graft Fu… (NCT06907758) | Clinical Trial Compass
RecruitingNot Applicable
Impact of Perioperative Organ Resuscitation of Brain-dead Deceased Organ Donor on Kidney Graft Function in the Recipient
France50 participantsStarted 2024-04-10
Plain-language summary
Brain-dead patients are the primary source of grafts for those awaiting organ transplantation. Recommendations exist for the management of these potential donors, based on the concept of organ resuscitation, according to which targeted resuscitation would improve graft quality and quantity.
Graft performance thus depends on fixed factors (donor/recipient age, medical history, etc.) but also potentially modifiable factors.
Through this study, the investigators aim to identify potentially modifiable factors in our donor care (in intensive care and the operating room) that may influence graft function in the recipient. For simplicity, the investigators will focus on kidney grafts. The aim is to improve the effectiveness of the transplant and reduce waiting times.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
The inclusion criteria for organ donor patients are as follows:
* Adult patient
* Brain dead
* Hospitalized in surgical intensive care at Strasbourg University Hospital (NHC cardiovascular intensive care unit, NHC multi-purpose intensive care unit, Hautepierre surgical intensive care unit) from January 1, 2018 to December 31, 2023
* Having undergone multi-organ transplantation
* At least one of the donor kidneys has been transplanted to a patient at Strasbourg University Hospital
* Absence of written objection in the medical file of the subject (and/or their legal representative, if applicable) to the reuse of their data for scientific research purposes.
The inclusion criteria for kidney transplant recipients are as follows:
* Adult patient
* Recipient of a kidney transplant from an organ donor who meets the inclusion criteria for donor patients mentioned above
* Patient who has undergone surgery and is hospitalized post-operatively at Strasbourg University Hospital
* Patient monitored by the Strasbourg University Hospital transplant team
* Absence of written objection in the subject's medical file (and/or their legal representative, if applicable) to the reuse of their data for scientific research purposes.
Exclusion Criteria:
* Subject (and/or their legal representative, if applicable) who has expressed their opposition to the reuse of their data for scientific research purposes
* Brain-dead patient who has not undergone organ retrieval
* Brain-dea…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Ratio of creatinine decrease
Timeframe: Days 1 and 2 in kidney transplant recipients