Weight Gain Prevention in Adolescents and Young Adults (NCT06905626) | Clinical Trial Compass
Not Yet RecruitingPhase 3
Weight Gain Prevention in Adolescents and Young Adults
140 participantsStarted 2026-11-01
Plain-language summary
The investigators believe they key to effective prevention of obesity is early identification of individuals at high risk of excess weight gain and proactive implementation of a comprehensive approach including lifestyle-based coaching and preventive medical management targeting the pathophysiology of dysregulated energy metabolism. In this study the investigators will take a fundamentally different approach to the science of obesity prevention by targeting the underlying biological processes driving unhealthy weight gain in adolescents/young adults (AYAs), a group that has been underrepresented in medication trials.
Who can participate
Age range
18 Years – 25 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 to M 25 at screening
* BMI \>/= 25 to \< 30 kg/m\^2
* Family history of obesity defined as one biological parent with severe obesity (BMI \>/= 35) and/or two biological parents with obesity (BMI \>/=30). Parental obesity status will be confirmed by obtaining a release of information to review and electronic health record.
Exclusion Criteria:
* Tanner stage 1-4
* Diabetes (type 1 or 2)
* Current or recent (\<6 months prior to screening) use of anti-obesity medication(s) or other weight-altering medication(s) (e.g. atypical anti-psychotics, attention deficit hyperactivity disorder (ADHD) stimulant)
* Previous bariatric surgery
* Current or recent (\<6 months prior to screening) use of medication(s) to treat insulin resistance
* Recent initiation (\<3 months prior to screening) of anti-hypertensive or lipid medication(s)
* History of glaucoma
* Current or recent (\<14 days prior to screening) use of monoamine oxidase inhibitor
* Known hypersensitivity to sympathomimetic amines
* History of treatment with growth hormone
* Patient Health Questionnaire-9 (PHQ-9) score of \>/= 15 at screening
* Eating disorder symptoms within 6 months and/or any past medical diagnosis of eating disorder
* Major psychiatric disorder
* Unstable clinically-diagnosed depression
* History of suicide attempt
* Suicidal ideation of type 4 or 5 on the Columbia-Suicide Severity Rating Scale (C-SSRS) at any time during the study
* Current pregnancy or breastfeeding
* Plans to b…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.