A Phase 4, Randomised Vaccination Study in Healthy Adults to Investigate the Effects of Acellular Pertussis Vaccine on Colonisation With Bordetella Pertussis Using Controlled Human Infection

Inclusion Criteria: * Participant (male/female) is born before 1-9-2004 and \< 50 years old on the day of screening * Participant has received all primary pertussis vaccines during childhood * Participant is in good health as confirmed by review of medical history and physical examination * Participant has adequate understanding of the procedures of the study and agrees to abide strictly thereby * Participant is able to answer all questions of the pre-consent questionnaire correctly * Participant is fully conversant in the Dutch language * Participant is capable and willing to give personal signed informed consent. * Participant is able to communicate by both mobile telephone and text messaging * Participant is willing and available to attend all study visits * Participant agrees to inform his/her general practitioner (GP) about participation in the study * Participant agrees to provide access to information regarding their vaccination background * Participant agrees to provide a treating physician access to all study-related information and data * Participant is able to arrive within 1h at the Radboudumc from his/her home address. The participant must have a home address and live in the Netherlands * Participant is able to arrive within 3h at the Radboudumc at any time between Bp inoculation until the day 28 post challenge visit * Participant is willing to take an antibiotic regimen after inoculation with Bp according to the study protocol * Participant is willing to use in…