Effects of Esketamine on the Incidence of Postoperative Delirium and Postoperative Sleep Disturba… (NCT06900205) | Clinical Trial Compass
WithdrawnNot Applicable
Effects of Esketamine on the Incidence of Postoperative Delirium and Postoperative Sleep Disturbance in Elderly Patients After Major Non-cardiac Surgery
Stopped: The trial protocol has undergone substantial revisions, including modifications to the primary outcome measure, which fundamentally alter the original study objectives. As these changes are not compatible with the initial registration, we
China0Started 2025-04-01
Plain-language summary
Postoperative delirium (POD) is a common surgical complication.It is associated with a range of negative outcomes such as delayed postoperative recovery,prolonged hospitalization,additional medical expenditures and higher mortality.
Meanwhile,sleep disorders are not only an important predisposing factor for delirium,but also one of the main symptoms of delirium.Systemic inflammatory responses caused by sleep disorders may be an important mechanism for POD.
Many studies have shown that esketamie may inhibit inflammatory factors and enhance neuroplasticity.
In summary,we felt the need to further explore the therapeutic potential of esketamine in the area of POD as well as postoperative sleep disorders.
Who can participate
Age range65 Years
SexALL
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Inclusion criteria
✓. Age ≧ 65 years;
✓. ASA â… -â…¢;
✓. Elective major non-cardiac surgery;
✓. Voluntary signed informed consent.
Exclusion criteria
✕. People with mental illness;
✕. Suffering from serious central nervous system disorders such as arkinson's disease, Alzheimer's disease, etc;
✕. Elevated intracranial pressure;
✕. Emergency or trauma surgery;
✕. Prior history of postoperative delirium or postoperative cognitive decline;
✕. The patient has impaired hearing or impaired vision;
✕. Suffering from severe systemic underlying diseases (e.g. cardiac insufficiency, malignant arrhythmia, malignant hypertension, hepatic failure, renal failure, etc.);