Assessing Chest Pain Using Point-of-Care High-Sensitivity Troponin I in the Emergency Department

Inclusion Criteria: * Age greater than or equal to18 years * Symptoms suggestive of acute coronary syndrome: * Acute chest, epigastric, neck, jaw or arm pain or discomfort or pressure without apparent non-cardiac source * Shortness of breath, nausea, vomiting, fatigue/malaise, or * Other equivalent discomfort suggestive of an myocardial infarction (MI) * Electrocardiogram (ECG) ordered as part of standard of care * At least one troponin collected as standard of care * Study specific blood sample collected within ± 5 minutes of clinical draw Exclusion Criteria: * ST-segment elevation myocardial infarction (STEMI) Activation * Unstable vitals signs: symptomatic hypotension at the time of enrollment (systolic \< 90 mm Hg), tachycardia (HR\>120), bradycardia (HR\<40), and hypoxemia (\<90% pulse-oximetry on room air or normal home oxygen flow rate) * Central laboratory hs-cTn testing resulted or in process (\>5 minutes) prior to study accrual * Prior enrollment * Terminal diagnosis with life expectancy less than 6 months