Active — Not RecruitingNot Applicable

Intracardiac Echocardiography-Guided Catheter Ablation for Premature Ventricular Contractions Originating From the Papillary Muscles

China156 participantsStarted 2025-03-23

Plain-language summary

This randomized, prospective, parallel, single-blind, multicenter clinical trial investigates the efficacy and safety of intracardiac echocardiography (ICE)-guided catheter ablation versus pressure-sensing catheter ablation alone in reducing PVC recurrence among patients with confirmed papillary muscle-originating premature ventricular contractions (PVCs). Participants were randomly allocated to either the ICE-guided intervention group or the conventional ablation control group following definitive diagnosis.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients aged ≥18 years. * Diagnosed with premature ventricular contractions (PVCs) originating from the papillary muscles. * Symptoms refractory to antiarrhythmic drug therapy. * Patients must be capable and willing to provide written informed consent for study participation. Exclusion Criteria: * History of cardiac surgery or any prior cardiac interventional procedures. * Ischemic heart disease, dilated cardiomyopathy, or hypertrophic cardiomyopathy. * Severe hepatic or renal dysfunction: AST/ALT \>3× upper limit of normal (ULN); Serum creatinine (SCr) \>3.5 mg/dl or creatinine clearance (Ccr) \<30 ml/min. * Prior ablation for papillary muscle PVCs. * Life expectancy \<1 year. * Pregnancy or lactation.

What they're measuring

Freedom from VC recurrence

Timeframe: Patients were followed up at 3 months postoperatively to assess recurrence.

Trial details

NCT IDNCT06898281

SponsorShanghai Chest Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-01