CompletedPhase 4

Effect of Dexmedetomidine and Total Intravenous Anesthesia on Endothelial Damage-Related Biomarkers

Turkey (Türkiye)90 participantsStarted 2025-04-10

Plain-language summary

This study aimed to evaluate whether dexmedetomidine has a protective effect on endothelial damage by measuring plasma syndecan1 and heparan sulphate levels in rhinoplasty patients who take propofol+remifentanyl infusion.

Who can participate

Age range18 Years – 50 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria:patients between the ages of 18-50 who will undergo rhinoplasty will be included in the study - Exclusion Criteria:patients who do not agree to participate in the study, patients with underlying peripheral arterial disease, coronary artery disease, hypertension, diabetes mellitus, and ASA (American Society of Anaesthesiologists) Classification ≥3 will be excluded. \-

What they're measuring

endothelial damage in patients under general anaesthesia

Timeframe: from preoperative 24 hours to postoperative 24 hours

Trial details

NCT IDNCT06897696

SponsorFirat University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-10-31

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