Efficacy of a Gel Containing Polynucleotides and Hyaluronic Acid in Supraosseous Periodontal Defects Treated with the Single Flap Approach

INCLUSION CRITERIA Patient-specific * age≥ 18 years; * diagnosis of Stage III or IV periodontitis22; * good physical status (ASA1 and ASA2 according to Physical Status Classification System); * systemic and local conditions compatible with periodontal surgical procedures; * patient willing and fully capable to comply with the study protocol. Site-specific * defect located in an incisor, canine or premolar region which becomes exposed during spontaneous smiling; * defect with an intrabony component (as assessed on periapical radiograph and confirmed intra-surgically) ≤ 2 mm; * defect with a radiographic CEJ-BC≥ 4 mm; d) residual (following step I-II of treatment) PD≥6 mm at both interproximal aspects facing the SD. EXCLUSION CRITERIA Patient-specific * poorly controlled diabetes (HbA1C ≥ 7%); * history of radiation therapy in the head and neck area; * history of chemotherapy; * systemic disease or conditions with a documented effect on bone metabolism and/or periodontal status/healing; * past (within 6 months prior to enrollment in the study) or current treatment with any medication with a documented effect on bone metabolism and/or periodontal status/healing; * physical or mental handicap that can interfere with adherence to the study procedures and adequate hygienic compliance; * documented allergy to dental materials involved in the experimental protocol; * pregnancy or lactation; * history of drug or alcohol abuse. Moreover, participants will be immediately excluded …