RecruitingNot Applicable

Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing

United States50 participantsStarted 2025-05-21

Plain-language summary

This single-arm, multi-center, prospective study will assess the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and determinants thereof (transit time, Pa, Pd) in patients before and after intracoronary nitroglycerine.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Aged 18 or older
✓. Patient being evaluated for ANOCA or INOCA
✓. Clinical suspicion for angina
✓. Patient should be able to comply with the protocol.
✓. Provide written informed consent before study participation.

Exclusion criteria

✕. Existing coronary artery disease
✕. Previous percutaneous interventions within the coronaries
✕. Current use (within 48 hours) of long-acting nitrate therapies
✕. Current use (within 48 hours) of PDE-5 inhibitors (sildenafil, tadalafil)
✕. Any other condition or co-morbidity which, in the opinion of the investigator or operator, may pose a significant hazard to the subject if he or she is enrolled in the study.
✕. Children below 18 years, prisoners, pregnant people and patients who are unable to provide consent are excluded.

What they're measuring

Assessment of CFR by CRT before and after nitrates

Timeframe: Intra op

Trial details

NCT IDNCT06896903

SponsorBaylor Research Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-05-01

Contact for this trial

Bonnie Ostergren

469-814-4181 Bonnie.Ostergren@bswhealth.org

View on ClinicalTrials.gov More ANOCA - Angina With Non-obstructive Coronary Arteries trials