Microbial Community Characteristics in Intestinal Mucosal Tissue of Patients With CD

Inclusion Criteria: * Patients with Crohn's disease undergoing endoscopic examination * Healthy individuals with no symptoms undergoing colonoscopy without any lesions detected * Patients undergoing small intestinal endoscopy due to symptoms but with negative examination results. * Age between 18 and 80 years. * Patients or authorized family members sign the relevant informed consent forms. Exclusion Criteria: * Patients with concurrent digestive system diseases that may affect the study results, including tumors, infections, or other autoimmune diseases. * Patients with concurrent non-digestive system diseases that may affect the study results, including tumors, infections, or autoimmune diseases. * Patients who have taken probiotics or antibiotics within the past week. * Patients with psychiatric disorders or other conditions that prevent them from cooperating with the study. * Patients participating in other clinical trials that may interfere with the results of this study.