This study is designed to compare the clinical effectiveness of unilateral and bilateral Greater Occipital Nerve Pulsed Radiofrequency (GON-PRF) treatment at the C2 level in patients with migraine. The procedure will be guided by ultrasound and will focus on evaluating how each technique affects migraine symptoms.
The main goal of this study is to assess the impact of both unilateral and bilateral GON-PRF treatments on migraine relief. Additionally, the secondary objectives of this study include evaluating the effects of these treatments on migraine-related disability and comparing any potential side effects or complications that may occur during the treatments.
This research will help us understand which technique may be more effective and provide more information on the safety of these treatments.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age between 18 and 65 years
* Followed at the Algology outpatient clinic of Ankara Bilkent City Hospital
* Diagnosis of episodic migraine (≥5 attacks per month) or chronic migraine according to ICHD-3 criteria
* Inadequate response to migraine preventive medications
* Not currently using preventive migraine medication OR no change in medication and/or dosage within the last 3 months
* No bleeding or coagulation disorders
* No active infection
* Not pregnant and not suspected of pregnancy
* No history of craniocervical surgery affecting the intervention area
* Able to understand the study and provide written informed consent
* Able to comply with study procedures and follow-up
Exclusion Criteria:
* Diagnosis of primary headache other than migraine according to ICHD-3 criteria
* Fewer than 5 migraine attacks per month
* Headache secondary to comorbid conditions (e.g., uncontrolled hypertension, intracranial lesions)
* Interventional migraine treatment within 3 months prior to GON-PRF
* Botulinum toxin injection within 3 months prior to GON-PRF
* Non-pharmacological migraine treatment (e.g., acupuncture, physical therapy, ozone therapy, cognitive behavioral therapy) within 3 months prior to GON-PRF
* Withdrawal of consent at any stage of the study
* Failure to attend follow-up visits
* Development of any condition that meets exclusion criteria during the study
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Mean change in monthly headache days from baseline to 6 months