RecruitingNot Applicable

Circadian Rhythms in Human Adipose

United States40 participantsStarted 2021-07-01

Plain-language summary

The goal of this study is to understand the underlying circadian rhythms in subcutaneous adipose tissue of humans with our without continuous feeding and how these are altered in people who have obesity.

Who can participate

Age range18 Years – 55 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * BMI 20-25 kg/m2 or 30-37 kg/m2 * For participants with obesity a waist-to-hip ratio of ≥0.95 in males and ≥0.90 in females. * sedentary * females: non pregnant or breastfeeding * ability to provide written informed consent and follow study instructions Exclusion Criteria: * History of mediations that impact adipocyte/lipid metabolism * smoking * insomnia * sleep apnea * sleep medication use * employment in night or shift work * extreme chronotypes * Allergy to lidocaine

What they're measuring

rhythmicity of circadian clock mRNA in adipose tissue

Timeframe: 24 hour

Trial details

NCT IDNCT06891534

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-12

Contact for this trial

Kelli A Lytle, PhD

507-255-1488 lytle.kelli@mayo.edu

View on ClinicalTrials.gov More Obesity, Abdominal trials