CompletedNot Applicable

Hysteroscopy for Chronic Endometritis: Diagnostic Performance and Observer Variability

Tunisia70 participantsStarted 2021-06-06

Plain-language summary

This study investigates the role of hysteroscopy in diagnosing chronic endometritis (CE), a condition linked to female infertility but difficult to diagnose due to nonspecific symptoms. While histological examination with CD138 ( Cluster of Differentiation 138 )immunohistochemistry is the gold standard, hysteroscopy remains widely used. This prospective, multicenter study included infertile women with no uterine abnormalities on ultrasound. Hysteroscopy was performed using standardized criteria, and its diagnostic performance was compared to histopathology. Intra- and inter-observer variability were also assessed through blinded video evaluations by two specialists. The study aimed to determine the reliability of hysteroscopy in diagnosing CE and its agreement among different observers.

Who can participate

Age range18 Years – 42 Years

SexFEMALE

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Inclusion Criteria: * included women aged 18 to 42 years, consulting for infertility, with a pelvic ultrasound showing no uterine abnormalities Exclusion Criteria: * Excluded from the study were patients with biological inflammatory syndrome, those on antibiotic therapy or with a recent acute genital infection (less than three months), autolysed biopsies, unusable hysteroscopy videos, atypical hyperplasia, or endometrial cancer.

What they're measuring

Proportion of Participants Undergoing Diagnostic Hysteroscopy

Timeframe: peroperatively

Expression of CD138 Marker in Endometrial Biopsy

Timeframe: First 24 hours

Trial details

NCT IDNCT06890754

SponsorTunis University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-08-01

View on ClinicalTrials.gov More Chronic Endometritis trials