Systemic Activation of Inflammasomes and Frailty in Older Candidates to Kidney Transplantation (NCT06887075) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Systemic Activation of Inflammasomes and Frailty in Older Candidates to Kidney Transplantation
France60 participantsStarted 2025-04-15
Plain-language summary
Kidney transplantation (KT) benefit-risk ratio assessment is a challenge in a growing population of older patients with end-stage kidney disease. A pre-KT frailty phenotype has been found predictive of post-KT complications, but biological mechanisms of frailty are poorly known is these patients. Frailty is associated with chronic low-grade inflammation in the older general population, possibly through the inflammasome pathway. Our main objective is to assess if systemic activation of inflammasomes is associated with frailty in older candidates to KT.
Who can participate
Age range
70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
* Inclusion criteria:
* Age ≥ 70
* Patient candidate to kidney transplantation (during assessment for inscription on the waiting-list, or during waiting time after effective inscription), without absolute contraindication
* Free, informed and written consent signed by the participant and the investigator (at the latest, on the day of inclusion and before any examination required by the research).
* Person affiliated or beneficiary of a social security scheme
* Exclusion criteria:
* Inclusion in an industrial study refusing co-inclusion in our study
* Person under guardianship, assisted decision-making or under temporary guardianship
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
IL1
Timeframe: at recruitment (up to 30 days)
2
IL18
Timeframe: at recruitment (up to 30 days)
3
inflammasomes genes
Timeframe: at recruitment (up to 30 days)
4
inflammasome platform
Timeframe: at recruitment (up to 30 days)
5
Weight
Timeframe: at enrollment (Day 0), at recruitment (up to 30 days)
6
Activity
Timeframe: at enrollment (Day 0), at recruitment (up to 30 days)
7
Gait
Timeframe: at enrollment (day 0), at recruitment (up to 30 days)
8
Handgrip strength
Timeframe: at enrollment (day 0), at recruitment (up to 30 days)