Kidney transplantation (KT) benefit-risk ratio assessment is a challenge in a growing population of older patients with end-stage kidney disease. A pre-KT frailty phenotype has been found predictive of post-KT complications, but biological mechanisms of frailty are poorly known is these patients. Frailty is associated with chronic low-grade inflammation in the older general population, possibly through the inflammasome pathway. Our main objective is to assess if systemic activation of inflammasomes is associated with frailty in older candidates to KT.
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IL1
Timeframe: at recruitment (up to 30 days)
IL18
Timeframe: at recruitment (up to 30 days)
inflammasomes genes
Timeframe: at recruitment (up to 30 days)
inflammasome platform
Timeframe: at recruitment (up to 30 days)
Weight
Timeframe: at enrollment (Day 0), at recruitment (up to 30 days)
Activity
Timeframe: at enrollment (Day 0), at recruitment (up to 30 days)
Gait
Timeframe: at enrollment (day 0), at recruitment (up to 30 days)
Handgrip strength
Timeframe: at enrollment (day 0), at recruitment (up to 30 days)