RecruitingPhase 1

Home-based Vision Therapy

United States45 participantsStarted 2026-01-14

Plain-language summary

Post-concussive vision symptoms affect many Veterans who have experienced traumatic brain injury (TBI). One common issue is trouble with near vision, a problem that may persist long after the acute injury. Double vision or difficulty focusing on close objects can affect reading and depth perception. Poor reading can interfere with academic or work performance, and loss of near focusing can affect jobs that require fine motor tasks like machining and electrical work. Even having trouble using a smartphone can have a substantial impact on both work and social function. Near vision impairment after TBI is not well understood, and treatments are limited. The goal of this project is to investigate novel virtual-reality assessments and training games to improve the near vision diagnosis and home-based rehabilitation. Restoring normal near vision function could have a large impact on the fulfillment of Veterans' educational, career, and overall life goals.

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * U.S. Military Veteran * Place of residence within driving distance of Cleveland, OH * Clinical eye exam within 6 months prior to enrollment and since the most recent TBI (if applicable) and the onset of near vision symptoms (if applicable) * Best-corrected visual acuity 20/25 or better in each eye * Convergence insufficiency (VR-NPC \< 32 deg) Exclusion Criteria: * Neurological condition other than TBI that would affect convergence * History of strabismus, amblyopia, or other binocular vision issues prior to TBI

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Vergence Capacity (VR-NPC)

Timeframe: At study onset, At completion of Block 1 (six weeks duration), At completion of Block 2 (six weeks duration)

System Usability Scale (SUS)

Timeframe: At completion of active treatment block (six-weeks duration)

Simulator Sickness Questionnaire (SSQ)

Timeframe: At completion of active treatment block (six-weeks duration)

Trial details

NCT IDNCT06886737

SponsorVA Office of Research and Development

Sponsor typeFED

Study typeINTERVENTIONAL

Primary completion2028-09-30

Contact for this trial

Mark F Walker, MD

(216) 791-3800 Mark.Walker5@va.gov

View on ClinicalTrials.gov More Convergence Insufficiency trials

Plain-language summary

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Vergence Capacity (VR-NPC)

Timeframe: At study onset, At completion of Block 1 (six weeks duration), At completion of Block 2 (six weeks duration)

System Usability Scale (SUS)

Timeframe: At completion of active treatment block (six-weeks duration)

Simulator Sickness Questionnaire (SSQ)

Timeframe: At completion of active treatment block (six-weeks duration)