CompletedNot Applicable

Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled Trial

Turkey (Türkiye)48 participantsStarted 2024-02-03

Plain-language summary

This study investigates a biological approach that allows infected and necrotic teeth to heal themselves instead of being treated with traditional root canal therapy. Traditional root canal treatment involves cleaning the infected tissue inside the tooth and sealing it with a filling material, whereas regenerative endodontic treatment is a novel approach that enables the tooth to repair itself. This treatment method involves inducing bleeding in the root area or applying special blood derivatives (PRF types) to accumulate healing-supporting cells and growth factors. The aim of the study is to compare the effects of different biological treatment methods on the healing process, postoperative pain, and tooth discoloration. The results may help develop more effective and aesthetically successful treatment options in the future.

Who can participate

Age range14 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Single-rooted teeth with mature teeth with necrotic pulp requiring endodontic treatment, and a periapical lesion (Periapical Index Score (PAI) ≥3). * Individuals without systemic diseases, not using antibiotics, corticosteroids, antidiabetic, or antihypertensive medications, and not pregnant. * Patients without acute pain. * Patients without extraoral swelling, sinus tract, or acute apical abscess. * Individuals willing to participate and able to attend follow-up sessions regularly. Exclusion Criteria: * Teeth with internal or external root resorption or vertical root fractures. * Immature teeth. * Individuals outside the age range of 14-65 years. * Patients with complicated systemic diseases or those using antibiotics, corticosteroids, antidiabetic, or antihypertensive medications. * Patients with acute pain, those who have taken analgesic medication in the last 24 hours, or those who have used antibiotics within two weeks before treatment. * Patients who are unlikely to attend follow-up sessions.

What they're measuring

Radiographic Assessment of Lesion Healing at 6 Months

Timeframe: Baseline and 6 months

Change in Pain Level at 24 Hours, 72 Hours, and 1 Week Post-Treatment

Timeframe: Post-Treatment at 24 Hours, 72 Hours, and 1 Week

Assessment of Tooth Discoloration at 6 Months

Timeframe: Baseline and 6 months

Trial details

NCT IDNCT06886438

SponsorSaglik Bilimleri Universitesi

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-03-10