The purpose of the study is to evaluate the routes and rate of elimination and recovery of total radioactivity (TRA) and characterize the Pharmacokinetic (PK) of VX-993 after a single oral dose of 14C-VX-993.
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Terminal Phase Rate Constant (λz) of VX-993 in Plasma
Timeframe: From Day 1 up to Day 25
Area Under the Concentration Versus Time Curve From the Time of Dosing to the Last Measurable Concentration (AUC0-tlast) of VX-993 in Plasma
Timeframe: From Day 1 up to Day 25
Area Under the Concentration Versus Time Curve From the Time of Dosing Extrapolated to Infinity (AUC0-inf) of VX-993 in Plasma
Timeframe: From Day 1 up to Day 25
Apparent Clearance (CL/F) of VX-993 in Plasma
Timeframe: From Day 1 up to Day 25
Maximum Observed Plasma Concentration (Cmax) of VX-993 in Plasma
Timeframe: From Day 1 up to Day 25
Time for VX-993 to Reach Maximum Concentration (Tmax) in Plasma
Timeframe: From Day 1 up to Day 25
Apparent Volume of Distribution (Vz/F) (Based on the Terminal Phase) of VX-993 in Plasma
Timeframe: From Day 1 up to Day 25
Terminal Phase Rate Constant (λz) of Total Radioactivity (TRA) in Whole blood and Plasma
Timeframe: From Day 1 up to Day 25
Amount of Radioactivity Excreted (Ae) of TRA in Urine, Feces and Vomitus (if applicable)
Timeframe: Pre dose up to Day 25
AUC0-tlast of TRA in Whole blood and Plasma
Timeframe: From Day 1 up to Day 25
AUC0-inf of TRA in Whole blood and Plasma
Timeframe: From Day 1 up to Day 25
CL/F of TRA in Whole blood and Plasma
Timeframe: From Day 1 up to Day 25
Renal Clearance (CLr) of TRA in Urine and Feces
Timeframe: Pre dose up to Day 25
Cmax of TRA in Whole blood and Plasma
Timeframe: From Day 1 up to Day 25
Fraction (percent) of Dose Excreted Unchanged in Urine of TRA
Timeframe: Pre dose up to Day 25
Tmax of TRA in Whole blood and Plasma
Timeframe: From Day 1 up to Day 25
Apparent Volume of Distribution (Based on the Terminal Phase) of TRA in Whole blood and Plasma
Timeframe: From Day 1 up to Day 25
Amount of VX-993 and Metabolites, Expressed as a percent of TRA, in Plasma, Urine and Feces
Timeframe: From Day 1 up to Day 25