Study of MCLA-129 in the Treatment of Advanced Non-small Cell Lung Cancer with AGA and MET Amplification.

Inclusion Criteria: * Subjects are ≥ 18 years of age, regardless of gender. * Subjects must have histologically or cytologically confirmed locally advanced unresectable or metastatic NSCLC. * Subjects who must experience disease progression or intolerance after standard treatment eligible through screening will be divided into the following 4 cohorts: Cohort 1 and Cohort 2: Patients with advanced NSCLC with previously detected EGFR-sensitive mutations (exon 19 deletion or exon 21 L858R mutation) who have progressed after prior standard treatment which includes 1) first-generation or second-generation EGFR-TKIs, with T790M mutation requiring third-generation EGFR-TKIs and platinum-based chemotherapy; or 2) first-generation or second-generation EGFR-TKIs, with T790M mutation negative or unknown status. Subjects in Cohort 1: Patients with MET amplification after failure of treatment with EGFR-TKIs. Subjects in Cohort 2: Patients who experienced disease progression or intolerance after MET inhibitors and benefited from such treatment. Cohort 3 and Cohort 4: Patients with advanced NSCLC with previously detected actionable gene alterations who had progressed after treatment with corresponding inhibitors and platinum-based chemotherapy. Subjects in Cohort 3: Patients with MET amplification after failure of treatment with the corresponding driver gene inhibitors. Subjects in Cohort 4: Patients who experienced disease progression or intolerance after MET inhibitors and benefite…