The acute subjective effects of serotonin (5-HT)2A receptor stimulation with psilocybin in humans are mostly positive. However, negative effects such as anxiety, paranoid thinking, or loss of trust towards other people are common effects, depending on the dose administered, the personality traits of the person consuming it (set), or the environment in which psilocybin is taken (setting). Negative psychedelic effects may cause acute distress to the subject and acute anxiety has been linked to less favorable long-term outcomes in patients experimentally treated with psilocybin or similar substances for the treatment of depression. The 5-HT and oxytocin releaser 3,4-methylenedioxymethamphetamine (MDMA) reliably induces positive mood, euphoria, comfort, empathy, and feelings of trust. If administered in combination with psilocybin, MDMA may increase positive subjective drug effects including positive mood, empathy, and trust and reduce negative emotions and anxiety associated with psilocybin and overall produce a more positive over negative experience. The present study will assess subjective and autonomic effects of psilocybin alone and in combination with MDMA.
Age range
25 Years – 65 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Acute Subjective effects I
Timeframe: through study completion, an average of 18 months
Acute Subjective effects II
Timeframe: through study completion, an average of 18 months
Acute Subjective effects III
Timeframe: through study completion, an average of 18 months
Acute autonomic effects I (blood pressure)
Timeframe: through study completion, an average of 18 months
Acute autonomic effects I (heart rate)
Timeframe: through study completion, an average of 18 months
Acute autonomic effects III (body temperature)
Timeframe: through study completion, an average of 18 months
Acute autonomic effects IV (ECG QT-time)
Timeframe: through study completion, an average of 18 months