Diagnostic Accuracy of the Optic Nerve Deformability Index and Optic Nerve Sheath Diameter as a N… (NCT06884319) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Diagnostic Accuracy of the Optic Nerve Deformability Index and Optic Nerve Sheath Diameter as a Noninvasive Predictor of Intracranial Pressure
Egypt50 participantsStarted 2025-03-01
Plain-language summary
The study will be carried out on 50 patients, dichotomized into high and normal ICP groups, and we will assess both ONSD and DI in all patients.
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion Criteria:
* age 18 to 65 years
* increased ICP (e.g., TBI, sub arachnoid hemorrhage, intracranial hemorrhage)
* a Glasgow Coma scale=3-12 and requiring ICP monitoring via invasive methods (e.g. extra ventricular drain, lumber drain)
Exclusion Criteria:
* chronic hydrocephalus
* extensive local orbit trauma
* a pre-existing ocular disease affecting the optic nerve and/or orbital cavity
* hyperthyroidism with exophthalmia
* facial trauma affecting the orbits and/or eyeballs
* optic nerve trauma
* signs of critically raised ICP, needing urgent surgery.
* hemodynamically unstable between ONSD acquisition and ICP measurement.
* receiving medication that would decrease ICP between ultrasound imaging and ICP measurement, i.e. mannitol, hypertonic saline or steroids.