Effects of Vibrating Mesh Nebulisation in Patients With COPD During Non-invasive Ventilation (VMN… (NCT06884228) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Effects of Vibrating Mesh Nebulisation in Patients With COPD During Non-invasive Ventilation (VMN-NIV)
United Kingdom12 participantsStarted 2025-04-08
Plain-language summary
Assessment of the effects of vibrating mesh nebulisation versus jet nebulisation on the electrical activity of the muscles involved in breathing (neural respiratory drive), breathing mechanics (respiratory impedance measured by forced oscillation technique), respiratory flow, heart rate and rhythm, spirometry and breathlessness symptoms in patients with chronic obstructive pulmonary disease who require non-invasive ventilation.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with COPD receiving home non-invasive ventilation for chronic respiratory failure under the Lane Fox Respiratory Service at Guy's and St Thomas' NHS Foundation Trust
* Tolerating home non-invasive ventilation for at least 4 hours/24 hours
* Aged 18-80 years old
* Able to communicate symptom burden to the research team
* Able to give informed consent for participation in the study
* Clinical stability, with no acute exacerbations of COPD for 2 weeks prior to enrolment
Exclusion Criteria:
* Severe, non-respiratory organ dysfunction including, but not limited to:
* Congestive cardiac failure
* Significant cardiovascular disease
* End-stage malignancy
* End-stage renal failure
* Acute pulmonary pathology requiring emergency treatment including, but not limited to:
* Pneumonia
* Pneumothorax
* Pulmonary embolism
* Severe cognitive impairment
* Psychosocial factors that would preclude completion of the study protocol
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is studying how a vibrating mesh nebulizer delivers medication during non-invasive ventilation for COPD — could you explain what 'neural respiratory drive' means and why measuring it matters for someone in my situation?
2Since this trial is listed as 'active, not recruiting,' does that mean enrollment is already closed, and if so, are there similar or follow-up studies I might still be eligible to join?
3This study doesn't have a traditional phase number, which seems to mean it's more of an observational or device-testing study — does that mean it's measuring how a delivery method works rather than testing a new drug, and how does that affect what risks or benefits I should weigh?
4If I'm already using non-invasive ventilation for my COPD, is a vibrating mesh nebulizer something my care team could consider for me now as part of standard care, or would I need to be in a trial to access it?
5How does participation in a study like this — which involves monitoring my breathing effort during nebulization — fit with my current COPD treatment plan, and would it require any changes to my existing medications or ventilation settings?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in neural respiratory drive
Timeframe: NRD assessed on both visits at baseline and 5, 15, 30 and 60 minutes after nebulisation