Osteopathic Manipulative Therapy Effects on Post-Acute Sequelae of COVID-19 (PASC) or Long COVID (NCT06883513) | Clinical Trial Compass
RecruitingNot Applicable
Osteopathic Manipulative Therapy Effects on Post-Acute Sequelae of COVID-19 (PASC) or Long COVID
United States20 participantsStarted 2025-05-01
Plain-language summary
This study is investigating the effects of using an Osteopathic Manipulative Therapy (OMT) treatment protocol that was shown to statistically improve smell in individuals suffering from Long-COVID olfactory (smell) dysfunction in a small single-blinded pilot trial conducted during 2021.
The questions this study is trying to answer are:
1. Does this OMT protocol improve other non-smell related Long-COVID symptoms
2. Do 2 OMT treatments improve Long-COVID symptoms more than 1 OMT treatment
Participants will:
1. Week 1: Take an digital survey regarding their Long-COVID symptoms undergo Long-COVID OMT treatment or a placebo treatment
2. Week 2: Take an digital survey regarding their Long-COVID symptoms then all will undergo Long-COVID OMT treatment
3. Week 3: Take an digital survey regarding their Long-COVID symptoms
4. Week 8: Take an digital survey regarding their Long-COVID symptoms
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* \- Individuals must claim they have had a prior positive SARS-CoV-2 test at least 6-weeks before the consenting process to proceed with the study
* Individuals must claim they have at least one of the following symptoms greater than 6-weeks post infection that is affecting their daily life(these symptoms correlate with the SBQ™-LC):
Symptoms of Long Covid Inclusion Criteria:
* Shortness of breath or Difficulty Breathing
* Difficulty with Movement (balance or tremor)
* Muscle Pain or stiffness
* Changes in sexual desire
* Worsening Generalized Pain
* Difficulty with Sleep
* Changes in Mood (anxiety or depression)
* Changes in Erectile function (Biological males only)
* Palpations (irregular heart beats)
* Altered Taste
* Changes in your Hair
* Changes in urination
* Dizziness
* Altered Smell
* Changes in Skin
* Changes in bowels
* Fatigue
* Indigestion
* Dry or irritated eyes
* Changes in sweating
* Difficulty with Cognition (memory or thinking)
* Stomach Pain
* Changes in menstruation (Biological females only)
* Chills or shivering
Exclusion Criteria:
* If anyone denies they have any of the above symptoms before consent, they will be excluded from the trial
* They will also be excluded from the trial if they have suffered any fractured bones in the last 3 months (this will further decrease risk to the patient as the patient will be moved by the physician during the treatment protocol)
* Participants who are enrolled in other Long-COVID trials t…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
The Symptom Burden Questionnaire™ for Long COVID (SBQ™-LC)
Timeframe: On arrival for baseline before any treatment (week 1). On arrival for 2nd treatment (week 2). 7 days after 2nd treatment (week 3). Final Survey on week 8 of post-enrollment
Trial details
NCT IDNCT06883513
SponsorUniversity of Louisville
Sponsor typeOTHER
Study typeINTERVENTIONAL
Primary completion2025-07-03
Contact for this trial
Michael E Stenta, DO, Doctor of Osteopathic Medicine