Radiographic and Histomorphometric Assessment for Alveolar Ridge Preservation Using Autogenous To… (NCT06879171) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Radiographic and Histomorphometric Assessment for Alveolar Ridge Preservation Using Autogenous Tooth Graft From Extracted Tooth Combined With Simvastatin 1:1 Versus Autogenous Tooth Graft
26 participantsStarted 2025-06-10
Plain-language summary
This study will be held to overcome the previous limitations related to bone loss after teeth extraction by taking advantages from both Autogenous tooth graft and Simvastatin which will offer a promising synergistic approach for reducing alveolar ridge resorption, enhance bone regeneration and ensuring implant site development for future implant placement. This combination will address the gap in knowledge and offering a novel approach in alveolar ridge preservation. The Autogenous tooth graft will provide a scaffold and growth factor source for bone regeneration while Simvastatin will promotes osteogensis and angiogensis at graft site. So The goal of the present trial aims to evaluate the first-time application of Autogenous tooth graft from extracted tooth combined with Simvastatin with a ratio 1:1(test group) versus Autogenous tooth graft alone (control group) at an extraction socket of non molar single rooted teeth for alveolar ridge preservation and implant site development prior to implant placement.
The participants will be divided into two groups:
Intervention Group will receive Autogenous tooth graft combine with Simvastatin with a ratio 1:1 Control Group will receive Autogenous tooth graft. with follow up period 4 months.
Who can participate
Age range
20 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with badly broken, non-restorable, or periodontally hopeless non molar single rooted teeth.
* Age from 20-45 years old(6,13). No sex predilection.
* Medically free from any medical condition that would interfere with bone healing.
* Patients with status classification (ASA I \& II) with adequate oral hygiene condition.
* Alveolar sockets free from any preexisting periapical pathology based on intraoral periapical or panoramic radiograph.
Exclusion Criteria:
* Patients with any medical condition that contraindicated the procedure and general contraindications for Implant Surgery(6,13)
* Patients who are allergic to Simvastatin drug.(6)
* Presence of active infection around the tooth or remaining root.
* Psychological reasons that might affect the procedure or the subsequent follow up visits.
* Heavy smokers
* Immunosuppressed or Immunocompromised.(13)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Horizontal bone width
Timeframe: 4 months after grafting
Trial details
NCT IDNCT06879171
SponsorCairo University
Sponsor typeOTHER
Study typeINTERVENTIONAL
Primary completion2025-12-10
Contact for this trial
Nourhan Mohamed Abd Elwahab, Bachelor of Dental Medicine