Not Yet RecruitingNot Applicable

Safety and Efficacy of Pulmonary Vein Isolation Using Pulsed-field Ablation (PFA) Combined with Either PFA-based Left Atrial Posterior Wall Isolation or Vein of Marshall Ethanol Ablation in Patients with Persistent Atrial Fibrillation

162 participantsStarted 2025-05

Plain-language summary

This study is designed to directly compare the safety and efficacy of PFA-based PVI+PWI vs PFA-based PVI+ VoM alcohol ablation in patients with Persistent AF.

Who can participate

Age range18 Years – 85 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Symptomatic persistent AF; 1st or redo ablation with PVI-only in the earlier procedure * Willing to provide informed consent * Age: 18-85 years Exclusion Criteria: * • Previous PWI or VoM ablation procedure * Left ventricular ejection fraction \<40% * Left atrial thrombus * Myocardial infarction within last 60 days * Cardiac surgery in the last 6 months * Advanced renal failure * Life expectancy \<1 year * Pregnant women * Unable or unwilling to provide informed consent

What they're measuring

Recurrence of atrial arrhythmia: any episode of AF/AT longer than 30 sec off-AAD, after the 2-month blanking period

Timeframe: 1 year

Trial details

NCT IDNCT06878924

SponsorTexas Cardiac Arrhythmia Research Foundation

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-05

Contact for this trial

Andrea Natale, MD

5125448186 dr.natale@gmail.com

View on ClinicalTrials.gov More Atrial Fibrillation (AF) trials