Role of Elastic Power in Acute Respiratory Distress Syndrome (NCT06878313) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Role of Elastic Power in Acute Respiratory Distress Syndrome
20 participantsStarted 2025-04-01
Plain-language summary
Mechanical ventilation is essential for managing acute respiratory distress syndrome (ARDS), but it can also cause ventilator-induced lung injury (VILI) due to mechanical forces. VILI results from the interaction between lung structure and mechanical ventilation factors, such as tidal volume, plateau pressure, driving pressure, inspiratory flow, respiratory rate, and PEEP. Intrinsic factors like lung heterogeneity further increase the risk.
Elastic power (EP), a key component, is linked to repetitive alveolar stretching and disease progression.
Study Objectives:
Examine the correlation between elastic power and pulmonary hyperinflation. Compare EP's sensitivity and specificity with other overdistension markers like driving pressure, plateau pressure, upper inflection point, and compliance.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria: Adult patients (≥18 years) with moderate-to-severe acute respiratory distress syndrome (ARDS), as defined by the Berlin criteria, were prospectively and consecutively included.
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Exclusion Criteria: Patients were excluded if they met at least one of the following criteria:
* History of emphysema, asthma, or pneumothorax.
* Severe instability at the time of the study preventing the PEEP titration maneuver, defined by at least one of the following indicators: SaO₂ ≤ 90%, shock requiring \>0.5 γ/kg/min of norepinephrine, complex arrhythmia, myocardial ischemia, or intracranial hypertension refractory to initial treatment.
* Patients with do-not-resuscitate orders and pregnant women.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is studying 'elastic power' and pulmonary hyperinflation in ARDS patients — can you explain what those measurements mean for my specific situation, and whether understanding them could change how my ventilator settings are managed?
2Since this trial is listed as 'not yet recruiting,' how much longer might it be before it actually starts enrolling patients, and is that timeline realistic given how quickly my condition may need to be addressed?
3This study is described as phase 'NA,' which often means it's observational rather than testing a new treatment — does that mean participating would mainly involve extra measurements and monitoring rather than a change to my actual care?
4Given that this trial focuses on moderate or severe ARDS, how does my current severity level factor into whether this kind of research participation would even be relevant to discuss, and are there standard-of-care options I should prioritize first?
5If I or a family member were to consider this trial once it opens, what would participation actually look like day-to-day — would it require additional procedures or significantly more time in the ICU compared to standard treatment alone?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
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Comparison between pulmonary hyperinflation and pulmonary elastic power