Not Yet RecruitingNot Applicable

Benefit of Ethanol Sclerotherapy of Endometriomas Before Ovarian Stimulation on Pregnancy Rates in IVF/ICSI

174 participantsStarted 2025-06-01

Plain-language summary

Evaluation of progressive pregnancy rates (with an embryo with cardiac activity at 12 weeks), on a first attempt at IVF/ICSI (fresh and frozen embryo transfers) following the discovery of one or two endometrioma(s) of 30 to 80 mm, without a history of cystectomy, and comparison between the two groups: ethanol sclerotherapy and therapeutic abstention

Who can participate

Age range

18 Years – 43 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Infertile women aged 18 to 43, * Presenting one or 2 endometriotic cysts of 30 mm to 80 mm long axis, confirmed by ultrasound and/or pelvic MRI and without signs of atypia, * With indication of IVF/ICSI, first IVF/ICSI after the discovery of endometriosis cyst(s), * Having given their consent. Exclusion Criteria: * A history of ovarian cystectomy, * A non-homogeneous cyst that cannot be punctured (risk of incomplete aspiration), * Complex adnexal image that cannot exclude an associated hematosalpinx (communicating hematosalpinx, tissue component), * A recent tubo-ovarian infection, * An active, untreated vaginal infection, * Anticoagulant treatment at a therapeutic dose, * All adult patients protected by law (under guardianship or curatorship), * Problems understanding the French language, * Participation in intervention research, * All patients not affiliated to the social security system.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

cumulative rate of active pregnancies

Timeframe: 12 weeks

Trial details

NCT IDNCT06878053

SponsorPoissy-Saint Germain Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-06-01

Contact for this trial

Nelly SWIERKOWSKI-BLANCHARD, MD

+33139275259 nelly.swierkowskiblanchard@ght-yvelinesnord.fr

View on ClinicalTrials.gov More Infertile Women Undergoing IVF or ICSI trials