Not Yet RecruitingNot Applicable

Topical Methotrexate with Fractional CO2 Laser in Treatment of Non Segmental Vitiligo

50 participantsStarted 2026-05-01

Plain-language summary

This prospective, within subject clinical trial aims to evaluate the efficacy of combining fractional CO2 laser with topical methotrexate versus topical methotrexate alone in treating non-segmental vitiligo. Patients with comparable lesions on both sides of their body will receive both treatments randomly assigned to each side. The study assesses repigmentation, safety, patient satisfaction, and quality of life over six months.

Who can participate

SexALL

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Inclusion Criteria: * Participants are patients aged 18-65 with stable non-segmental vitiligo, having comparable lesions on both sides of their body. They must not have received corticosteroid or phototherapy treatments in the last three months and must provide informed consent. Exclusion Criteria: * Exclusion criteria include other skin diseases, pregnancy, severe organ dysfunction, compro

What they're measuring

percentage of repigmentation

Timeframe: 6months

Trial details

NCT IDNCT06877455

SponsorAssiut University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-11-30

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