CompletedNot Applicable

Low Sirtuin-1 Levels Are Linked to Erythropoietin Resistance in Hemodialysis Patients.

Turkey (Türkiye)391 participantsStarted 2020-08-01

Plain-language summary

This study investigates the relationship between Sirtuin-1 (SIRT1) levels and erythropoietin resistance in hemodialysis patients. The study aims to determine whether low SIRT1 levels contribute to EPO resistance and to explore the potential mechanisms involved. Blood samples and clinical data from hemodialysis patients will be analyzed to evaluate this relationship.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged ≥18 years * Receiving hemodialysis * Availability of laboratory data to calculate ERI Exclusion Criteria: * Autosomal polycystic kidney disease * Malignancies * Infectious diseases * Chronic rheumatological disorders * Vitamin B12 or folic acid deficiency * CRP levels ≥ 5 mg/L * PTH levels ≥ 300 pg/dL * Inadequate hemodialysis (Kt/Vurea \< 1.2)

What they're measuring

Sirtuin-1 levels

Timeframe: Measured at baseline (initial blood sample)

Trial details

NCT IDNCT06877286

SponsorCuma Bulent Gul

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-03-30

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